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Mouse Anti-Porcine Interleukin 1 Receptor Antagonist (IL1RN) Monoclonal Antibody

Cat. No.VD11N452

Product TypeAnimal-targeted Antibodies

Size

Product Overview

BioVenic mouse monoclonal antibody is specific for porcine interleukin 1 receptor antagonist. It is affinity purified by protein A. It can be applied to WB, IHC and IF/ICC assays of porcine interleukin 1 receptor antagonist.

Specifications

Application WB; IHC; IF/ICC
Clonality Monoclonal
Classification Primary Antibody
Clone D27N37
Host Mouse
Target Species Porcine
Species Reactivity Porcine
Specificity Porcine Interleukin 1 Receptor Antagonist
Immunogen Recombinant protein of interleukin 1 receptor antagonist
Purification Protein A Purified
Conjugation Unconjugated
Preservative and Stabilizer 0.05% Proclin 300
Buffer 0.01M Phosphate Buffered Saline, pH 7.4, 50% Glycerol
Physical State Liquid

Target Information

Porcine interleukin 1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor that plays a pivotal role in modulating the inflammatory response in pigs. As a member of the interleukin 1 family, IL-1Ra is secreted by various cell types, including immune cells, epithelial cells, and adipocytes. It functions by competitively inhibiting the binding of IL-1α/β to the IL-1 receptor (IL-1R1), thereby preventing the initiation of inflammatory signaling. This protein is particularly important in the context of diseases such as porcine reproductive and respiratory syndrome virus (PRRSV), where it is induced as an early immunomodulatory cytokine, potentially involved in the immunopathogenesis of PRRSV infections.

Target Porcine Interleukin 1 Receptor Antagonist
Target Synonym IL1RN
Gene ID 397499
UniProt ID Q29056

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Nedumpun, Teerawut, et al. "Negative immunomodulatory effects of type 2 porcine reproductive and respiratory syndrome virus-induced interleukin-1 receptor antagonist on porcine innate and adaptive immune functions." Frontiers in Immunology 10 (2019): 579.
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