This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Mouse Anti-Swine CD172a Monoclonal Antibody
Product Overview
O12H30 monoclonal antibody is specific for Swine CD172a, also know as Swine SIRPA or BIT. It was purified by affinity chromatography on Protein A from tissue culture supernatant. It can be applied for Flow Cytometry (FC); Immunohistochemical (IHC); Immunoprecipitation (IP) and Western Blot (WB).
Specifications
Target Information
CD172a, also known as signal-regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons. The gene coding for swine SIRPα has been mapped to porcine chromosome 17, in a region syntenic to the human chromosome 20 where SIRP genes have been mapped. CD172a acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 which plays an important role in involving in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.
Shipping and Storage
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt (up to 12 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
References
- Marquet, Florian, et al. "Characterization of dendritic cells subpopulations in skin and afferent lymph in the swine model." PloS one 6.1 (2011): e16320.