Mouse Anti-Porcine NCX1 Monoclonal Antibody

Porcine NCX1, or the sodium-calcium exchanger, is a crucial membrane transporter that plays a significant role in regulating cellular calcium homeostasis in various tissues, including the heart and smooth muscle. This protein is essential for maintaining the balance of calcium flux across the sarcolemmal membrane during excitation-contraction coupling, which is vital for muscle contraction and relaxation. In the cardiovascular system, NCX1 contributes to the regulation of intracellular Ca2+ levels, which is critical for maintaining mechanical activity and normal electrical rhythm in the heart. It operates in either Ca2+ exit mode or Ca2+ entry mode, depending on the membrane potential and ion gradients across the plasma membrane.