Mouse Anti-Porcine ATP-Citrate Synthase (ACLY) Monoclonal Antibody

ATP-citrate synthase (ACLY) is a key regulatory enzyme involved in the conversion of citrate to cytosolic acetyl-CoA, a reaction that is essential for fatty acid synthesis and cholesterol production. This enzyme catalyzes the ATP-dependent cleavage of citrate to yield acetyl-CoA and oxaloacetate, with the acetyl-CoA serving as a building block for fatty acid synthesis and cholesterol while the oxaloacetate can enter the tricarboxylic acid (TCA) cycle. ACLY is a critical node in metabolic pathways, integrating signals from various cellular processes, including nutrient availability and energy status. Its activity is tightly regulated at multiple levels, including transcriptional, post-translational, and allosteric mechanisms, to balance the cellular demand for lipid production and energy metabolism.