Mouse Anti-Porcine Huntingtin Interacting Protein 1 (HIP1) Monoclonal Antibody

Porcine huntingtin interacting protein 1 (HIP1) is a crucial protein that interacts with the huntingtin protein (HTT), which is associated with Huntington's disease (HD). HIP1 plays a significant role in intracellular transport and receptor endocytosis, and its interaction with HTT is implicated in the pathology of HD. The normal HTT-HIP1 interaction is essential for maintaining cellular functions, and its disruption in HD may lead to cytoskeletal defects and impaired membrane receptor trafficking in the brain, ultimately contributing to neuronal cell death. In pigs, HIP1 may serve as a key factor in the development and progression of HD-like symptoms, providing a valuable large animal model for studying the disease. The interaction between HTT and HIP1 is crucial for various cellular functions, and the disruption caused by the mutation in HTT can affect the function of both proteins. HIP1 has also been implicated in other medical conditions, including tumorigenesis and rheumatoid arthritis, highlighting its broad implications in health and disease.