Mouse Anti-Canine Protein Disulfide Isomerase (PDI) Monoclonal Antibody

Canine protein disulfide isomerase (PDI) is a thioredoxin-fold enzyme that plays a critical role in protein folding and disulfide bond formation within the endoplasmic reticulum. It is involved in the reduction, isomerization, and oxidation of disulfide bonds in proteins, which is essential for their proper folding and function. PDI has been implicated in various cellular processes, including the response to oxidative stress and the regulation of cell death pathways such as ferroptosis, an iron-dependent form of regulated cell death. In the context of canine health, PDI has been associated with neurodegenerative disorders like degenerative myelopathy, where it co-localizes with misfolded superoxide dismutase 1 (SOD1) aggregates, suggesting a role in the cellular defense against protein misfolding. This enzyme's activity and regulation are vital for maintaining protein homeostasis, and its dysregulation can be linked to the pathogenesis of various diseases, making PDI a potential therapeutic target for conditions involving protein misfolding and oxidative stress in dogs.