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Mouse Anti-Canine Ryanodine Receptor Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for canine ryanodine receptor. It can be applied to WB, ICC/IF, IHC and IP assays of canine ryanodine receptor.
Specifications
Target Information
Canine ryanodine receptor (RyR) is a critical calcium release channel in cardiac and skeletal muscle, essential for excitation-contraction coupling. It is a macromolecular complex that includes kinases and phosphatases, with phosphorylation playing a key role in its regulation. Dysfunction of RyR, particularly RyR2 in the heart, can lead to conditions such as malignant hyperthermia and muscular dystrophy. In dogs, mutations in the RYR1 gene have been associated with malignant hyperthermia, highlighting the importance of RyR in canine health. Stabilizing RyRs has shown potential in improving cardiac function in canine models of Duchenne muscular dystrophy, indicating its therapeutic potential.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.