Mouse Anti-Porcine Toll-Like Receptor 4 (TLR4) Monoclonal Antibody

Porcine toll-like receptor 4 (TLR4) is a pivotal immune receptor found in pigs, playing a crucial role in the innate immune response. TLR4 is a transmembrane protein that recognizes pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) from Gram-negative bacteria, and damage-associated molecular patterns (DAMPs), which are released from damaged host cells. Upon activation, TLR4 initiates a signaling cascade that leads to the production of pro-inflammatory cytokines, chemokines, and the activation of the adaptive immune system. The receptor's function is critical in the early detection of infections and the subsequent mobilization of the immune response. TLR4 is also implicated in the regulation of inflammation and tissue repair, making it a significant target for research into infectious diseases, sepsis, and inflammatory conditions in pigs. Its involvement in the recognition of both exogenous and endogenous danger signals underscores its importance in the maintenance of homeostasis and the prevention of autoimmunity.