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Mouse Anti-Porcine Squalene Epoxidase (SQLE) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for squalene epoxidase. It is affinity purified by protein A. It can be applied to WB, IF and ELISA assays of squalene epoxidase.
Specifications
Target Information
Porcine squalene epoxidase (SQLE) is a key enzyme involved in the cholesterol biosynthesis pathway in pigs. SQLE catalyzes the conversion of squalene to 2,3-oxidosqualene, which is a critical step in the production of cholesterol and other sterols. This enzyme is located in the endoplasmic reticulum and plays a central role in the regulation of cholesterol homeostasis within cells. Cholesterol is an essential component of cell membranes, and it is also required for the synthesis of steroid hormones, bile acids, and vitamin D. SQLE's activity is tightly regulated to ensure that the cellular demand for cholesterol is met without causing an accumulation that could lead to detrimental effects.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Padyana, Anil K., et al. "Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase." Nature communications 10.1 (2019): 97.