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VenicMAb™ Chimeric Mouse Anti-Canine VEGF Monoclonal Antibody-B08

Cat. No.VDQ5M1

Product TypeAnimal-targeted Antibodies

Size

Product Overview

BioVenic's VenicMAb™ Chimeric Mouse Anti-Canine VEGF Monoclonal Antibody is a chimeric monoclonal antibody combining the constant domains of the Canine IgG2 molecule with mouse variable regions. The variable region was obtained from a mouse immunized with purified, recombinant Human VEGF. The antibody was produced using recombinant antibody technology.

Specifications

Clonality Monoclonal Antibody
Classification Primary Antibody
Host Recombinant
Target Species Canine
Specificity Canine VEGF
Isotype Canine IgG2 kappa
Purification Protein A Purified
Purity ≥ 95% (HPLC)
Conjugation Unconjugated
Buffer PBS
Physical State Liquid

Target Information

Canine Vascular Endothelial Growth Factor (VEGF) is a crucial protein involved in angiogenesis, the process by which new blood vessels form from pre-existing ones. This protein plays a significant role in both normal physiological processes and pathological conditions, such as cancer, where it promotes tumor growth by enhancing blood supply. Anti-canine VEGF monoclonal antibodies could be targeted therapies specifically bind to VEGF, inhibiting its activity and thereby preventing tumor vascularization. This could be a potential approach that holds promise for improving cancer treatment outcomes in dogs, offering a more effective and targeted strategy to manage malignancies.

Target Canine VEGF
Target Synonym Vascular endothelial growth factor A; Vascular permeability factor (VPF); VEGFA
Gene ID 403802
UniProt ID Q9MYV3

Shipping and Storage

This product is shipped with dry ice. It is recommended to store at -80 °C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Maiolini, Arianna, et al. "Interleukin-6, vascular endothelial growth factor and transforming growth factor beta 1 in canine steroid responsive meningitis-arteritis." BMC Veterinary Research 9 (2013): 1-10.
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