Mouse Anti-Porcine Neuregulin 1 (NRG1) Monoclonal Antibody

Porcine neuregulin 1 (NRG1), also known as glial growth factor or heregulin, is a signaling protein that belongs to the epidermal growth factor (EGF) family. It plays a pivotal role in the development and maintenance of the nervous system, particularly in the context of neuron survival, migration, and synaptic plasticity. NRG1 is essential for the formation and function of myelin sheaths in peripheral nerves, which are crucial for the proper conduction of nerve impulses. This protein exerts its effects by binding to and activating specific tyrosine kinase receptors, such as ErbB2, ErbB3, and ErbB4, on the surface of cells. The activation of these receptors leads to a cascade of intracellular signaling events that regulate gene expression, cell growth, and differentiation. In the porcine model, NRG1 is particularly important for understanding the molecular mechanisms underlying neural development and myelination, which are critical for the overall health and productivity of pigs.