Mouse Anti-Porcine Peptidylprolyl Cis-Trans Isomerase (PIN1) Monoclonal Antibody

Porcine peptidylprolyl cis-trans isomerase (PIN1), also known as cyclophilin, is an essential enzyme involved in the folding of proteins within cells. This enzyme catalyzes the cis-trans isomerization of proline peptide bonds, a critical step in protein folding that can otherwise be a rate-limiting process. The activity of PIN1 ensures that proteins achieve their correct three-dimensional structure, which is vital for their function. In pigs, PIN1 plays a role in a variety of biological processes, including immune response and cellular differentiation. It has been identified in mammalian tissues and purified from porcine kidney, highlighting its prevalence and importance across species. The enzyme's activity is sensitive to the presence of cyclosporin A (CsA), a known immunosuppressive agent, suggesting a link between PIN1 function and the modulation of immune responses.