Mouse Anti-Porcine Toll Interacting Protein (TOLLIP) Monoclonal Antibody

Porcine toll interacting protein (TOLLIP) is an intracellular adaptor protein that plays a significant role in the modulation of immune responses, particularly in the Toll-like receptor (TLR) signaling pathway. As a key negative regulator, TOLLIP helps to prevent excessive inflammatory reactions by inhibiting the activation of NF-κB, a critical transcription factor in the immune response. TOLLIP interacts with various components of the TLR pathway, including MyD88 and IRAK1, to suppress the downstream signaling that leads to the production of pro-inflammatory cytokines. This interaction is crucial for maintaining immune homeostasis and preventing autoimmune disorders. The protein is also implicated in the regulation of autophagy and vacuole trafficking, which are important for cellular maintenance and the clearance of pathogens.