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Mouse Anti-Canine Endothelin 1 Monoclonal Antibody

Cat. No.VD11N111

Product TypeAnimal-targeted Antibodies

Size 100 μL

Product Overview

BioVenic mouse monoclonal antibody is specific for canine endothelin 1. It can be applied to WB, ICC/IF, IHC and FACS assays of canine endothelin 1.

Specifications

Application WB; ICC/IF; IHC; FACS
Clonality Monoclonal
Classification Primary Antibody
Clone S13N63
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine Endothelin 1
Isotype IgG1
Immunogen Recombinant protein of endothelin 1
Concentration 2.5 mg/mL
Conjugation Unconjugated
Preservative and Stabilizer 0.05% Sodium Azide
Buffer Phosphate Buffered Saline
Physical State Liquid

Target Information

Canine endothelin 1 (ET-1) is a potent 21-amino-acid vasoactive peptide that plays a significant role in various physiological and pathological processes in dogs, particularly in the cardiovascular and renal systems. It is primarily produced in vascular endothelial cells and acts as a strong vasoconstrictor, but it is also produced in organs such as the heart and kidney. Elevated levels of ET-1 have been associated with chronic kidney disease and suggested as a biomarker for hypertension in dogs. Additionally, in canine osteosarcoma, ET-1 signaling is active and promotes cellular migration, survival, proliferation, and bone alkaline phosphatase activities, suggesting a protumorigenic role.

Target Canine Endothelin 1
Target Synonym ET-1; EDN1; Preproendothelin-1; PPET1
Gene ID 403424
UniProt ID P13206

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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