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Rabbit Anti-Swine IL5 Polyclonal Antibody
Product Overview
O17H80 polyclonal antibody is specific for Swine Interleukin 5 (IL-5), also known as eosinophil differentiation factor (EDF). It was purified by affinity chromatography on Protein A from tissue culture supernatant. It can be applied for Western Blot (WB).
Specifications
Target Information
Interleukin 5 (IL-5), also known as eosinophil differentiation factor (EDF) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 expression seems to be very low in normal swine, but after induction of allergic late-phase reactions in sensitized animals, IL-5 expression in peripheral blood lymphocytes after polyclonal stimulation was detected. Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion-primarily IgA. IL-5 is also a key mediator in eosinophil activation. IL-5 is a cytokine that promotes eosinophil differentiation, proliferation, and survival and is important for the recruitment of eosinophils to the air-ways.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at -20 °C on receipt (up to 12 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Cortes, Lizette M., et al. "Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis." Frontiers in Allergy 3 (2022): 1029184.