Recombinant African Swine Fever Virus Inner Membrane Protein pE248R, C-Fc

African swine fever virus inner membrane Protein pE248R is an integral membrane protein that is essential for virus infectivity and early post-entry events. It is localized at the inner envelope of the virus particle and is involved in the fusion step of virus invasion, which is critical for the delivery of the viral core into the host cell's cytoplasm. The protein also plays a role in the immune evasion mechanisms of ASFV by inhibiting the cGAS-STING-mediated innate immune response, thereby suppressing the host's innate immune reaction and facilitating viral replication. In veterinary medicine, understanding the function of pE248R is crucial for developing strategies to control ASFV infection and for the design of vaccines targeting viral entry and immune modulation.