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Recombinant African Swine Fever Virus mRNA-capping Enzyme, N-His
Product Overview
BioVenic's Recombinant African Swine Fever Virus mRNA-capping Enzyme, N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 34. 8 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
African swine fever virus mRNA-capping enzyme is essential for the virus's replication and immune evasion. It ensures the stability and translation of viral mRNA by adding a methylguanosine cap to the 5' end, which is crucial for mRNA splicing, nuclear export, and protection from degradation. This enzyme helps the virus evade host immune responses by mimicking host mRNA, thereby preventing recognition by cellular pattern recognition receptors that trigger innate immunity. In veterinary medicine, understanding and targeting this enzyme could be key to developing therapeutics and vaccines against ASFV.
Shipping and Storage
This product is shipped with dry ice. Avoid repeated freezing and thawing. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.Aliquote the reconstituted solution to minimise freeze-thaw cycles.
References
- Yu, L. et al.Structure-function analysis of the triphosphatase component of vaccinia virus mRNA capping enzyme. Journal of virology1997: 9837-43,71,12