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Recombinant Canine Protein-Glutamine Gamma-Glutamyltransferase K (TGM1), N-His-GST
Product Overview
BioVenic's Recombinant Canine Protein-Glutamine Gamma-Glutamyltransferase K (TGM1), N-His-GST is a recombinant protein expressed from E.coli. Its predicted molecular weight is 57.5 kDa. The purity is>95% (SDS-PAGE).
Specifications
Target Information
Canine protein-glutamine gamma-glutamyltransferase K, also known as Transglutaminase 1 (TGM1), is an enzyme that catalyzes the transfer of the gamma-glutamyl moiety from glutamine to various target proteins, leading to protein cross-linking. This process is crucial for protein stabilization and the formation of insoluble protein networks in various biological systems. In dogs, TGM1 plays a significant role in skin health, as it is involved in the cross-linking of keratin, a major structural protein in the epidermis. It also contributes to wound healing and tissue repair through its action on extracellular matrix proteins. Additionally, TGM1 has been implicated in various physiological processes, including blood coagulation and the maintenance of tissue integrity.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL.Aliquote the reconstituted solution to minimise freeze-thaw cycles.