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Recombinant Canine Tumor Necrosis Factor Receptor Superfamily Member 5 (CD40), C-Fc
Product Overview
BioVenic's Recombinant Canine Tumor Necrosis Factor Receptor Superfamily Member 5 (CD40), C-Fc is a recombinant protein expressed from HEK293 Cell. Its predicted molecular weight is 46.1 kDa. The purity is>95% (SDS-PAGE).
Specifications
Target Information
Canine Tumor Necrosis Factor Receptor Superfamily Member 5 (CD40) is a key immune receptor expressed on antigen-presenting cells (APCs) and B cells in dogs. It plays a crucial role in immune activation by binding to CD40 ligand (CD40L) on T cells, promoting dendritic cell maturation and T cell activation. In veterinary medicine, CD40 is targeted in cancer immunotherapy, where agonist anti-CD40 antibodies are used to enhance antitumor immunity. This approach has shown promise in treating canine malignant melanoma, with studies demonstrating tumor regression and improved survival rates. Additionally, CD40 activation promotes B cell proliferation and antibody production, supporting overall immune function.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -20°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquot the reconstituted solution to minimize freeze-thaw cycles.