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Recombinant Chicken Insulin-Like Growth Factor-Binding Protein 2 (IGFBP2), N-His
Product Overview
BioVenic's Recombinant Chicken Insulin-Like Growth Factor-Binding Protein 2 (IGFBP2), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 33.5 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Chicken insulin-like growth factor-binding protein 2 (IGFBP2) is a critical regulator of the insulin-like growth factor (IGF) system, expressed in various tissues such as liver, muscle, kidney, heart, ovary, brain, and intestine. IGFBP2 binds to IGF-1 and IGF-2, modulating their biological activities and influencing cell proliferation, differentiation, and survival. In chickens, IGFBP2 produced in the liver appears to inhibit body growth, while locally produced IGFBP2 in the pectoral muscle promotes tissue development. Additionally, IGFBP2 plays a significant role in the chicken ovary, affecting follicle development and steroidogenesis. Studies show that IGFBP2 expression significantly increases in granulosa cells after follicle selection, promoting cell proliferation and inhibiting apoptosis, while regulating the expression of genes involved in progesterone synthesis. These findings indicate that IGFBP2 is crucial in chicken follicle development and reproductive processes.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL.Aliquote the reconstituted solution to minimise freeze-thaw cycles.