Recombinant Feline Macrophage Colony-Stimulating Factor 1 Receptor (CSF1R)

Feline Macrophage Colony-Stimulating Factor 1 Receptor (CSF1R) is a type I transmembrane receptor that is crucial for the development, function, and survival of macrophages and their precursors in cats. This receptor is activated by binding to its ligands, CSF-1 and IL-34, which triggers intracellular signaling pathways that regulate cellular proliferation, differentiation, and activation. CSF1R plays a vital role in the immune response, particularly in the innate immune system, by controlling the number and activity of macrophages. It is also implicated in the pathogenesis of various diseases, including certain types of cancer and inflammatory conditions. In veterinary medicine, understanding CSF1R's function is key to developing targeted therapies for feline diseases involving macrophage dysregulation.