Recombinant Mouse Chitinase-Like Protein 3 (Chil3), C-His

Mouse Chitinase-Like Protein 3 (Chil3) is a protein involved in inflammation and tissue repair. It is expressed in various cells, including macrophages and epithelial cells, and is induced upon exposure to pathogens or tissue damage. Chil3 exhibits chitinase activity and can degrade chitin, a component of fungal cell walls and parasite exoskeletons. This activity contributes to host defense against infections. Additionally, Chil3 is implicated in the regulation of immune responses, influencing the activation and polarization of macrophages. Research suggests that Chil3 may promote alternatively activated macrophages, which are associated with tissue repair and wound healing. Its expression is elevated in certain inflammatory diseases and cancer, where it may contribute to disease progression by modulating the inflammatory microenvironment. Understanding the roles of Chil3 in immunity and inflammation could provide insights into potential therapeutic targets for related conditions.