Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 1A (TNFRSF1A)

Mouse Tumor Necrosis Factor Receptor Superfamily Member 1A, or TNFRSF1A, is a tumor necrosis factor receptor involved in immune responses and apoptosis regulation. In mouse models, TNFRSF1A is studied for its roles in inflammation and autoimmune diseases. TNFRSF1A binds to tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine involved in the regulation of immune cell activation, inflammation, and programmed cell death. Mutations in TNFRSF1A have been associated with various inflammatory disorders, including TNF receptor-associated periodic syndrome (TRAPS). The receptor's signaling pathways can lead to both pro-inflammatory and pro-apoptotic outcomes, depending on the cellular context and the availability of other signaling molecules. Research on TNFRSF1A aims to elucidate the mechanisms by which it modulates immune responses and contributes to disease pathogenesis, with potential applications in developing targeted therapies for inflammatory and autoimmune conditions.