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Mouse Anti-Canine Calpastatin Monoclonal Antibody

Cat. No.VD11N193

Product TypeAnimal-targeted Antibodies

Size 100 μL

Product Overview

BioVenic mouse monoclonal antibody is specific for canine calpastatin. It can be applied to WB, ICC/IF and IHC assays of canine calpastatin.

Specifications

Application WB; ICC/IF; IHC
Clonality Monoclonal
Classification Primary Antibody
Clone S15N34
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine Calpastatin
Isotype IgG2
Immunogen Recombinant protein of calpastatin
Conjugation Unconjugated
Preservative and Stabilizer 0.05% Sodium Azide
Buffer Phosphate Buffered Saline
Physical State Liquid

Target Information

Canine calpastatin is the endogenous inhibitor of the calpain protease system, which is crucial in regulating muscle protein degradation. It plays a significant role in maintaining muscle integrity and is hypothesized to influence the expression of calpain system components in skeletal muscle. Nutrition has been shown to affect calpastatin expression, suggesting that dietary interventions could modulate calpain activity in dogs. As calpastatin is the only known specific inhibitor of conventional calpains, it is a key target for therapeutic strategies aimed at managing muscle wasting and diseases associated with calpain overactivity, such as muscular dystrophy in canines.

Target Canine Calpastatin
Target Synonym CAST; Calpain inhibitor
Gene ID 479148
UniProt ID A0A8C0N8I6

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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