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Mouse Anti-Canine Caseinolytic Protease P (CLPP) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for canine caseinolytic protease P. It can be applied to WB, ICC/IF and FACS assays of canine caseinolytic protease P.
Specifications
Target Information
Canine caseinolytic protease P (ClpP) is a mitochondrial serine protease that plays a significant role in protein homeostasis and mitochondrial functionality. It forms a complex with the AAA+ ClpX chaperone, known as ClpXP, which is crucial for degrading misfolded or damaged proteins within the mitochondria. Recent studies indicate that ClpP is upregulated in various tumors and supports tumor cell proliferation. Its overexpression has been linked to desensitization to cisplatin, a chemotherapy drug. Modulators of ClpP activity, both activators and inhibitors, can impair oxidative phosphorylation in cancer cells and induce apoptosis, suggesting its potential as a therapeutic target.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.