Mouse Anti-Canine Calcitonin Gene Related Peptide (CGRP) Monoclonal Antibody

Canine calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide that functions as one of the most potent endogenous vasodilators, with significant vasodilatory and anti-inflammatory properties. It is abundant in the pulmonary arteries and serves as the major vasodilator in the lungs. CGRP is primarily found in C and Aδ sensory fibers and acts as the main neurotransmitter of sensory nerves, with receptors including the calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1), which are distributed throughout the cardiovascular system. Targeting CGRP in dogs may offer insights into its role in vasodilation, inflammation, and pain management, with implications for the development of therapeutic strategies in veterinary medicine.