Mouse Anti-Canine Sodium Potassium ATPase Monoclonal Antibody

Canine sodium potassium ATPase (Na, K-ATPase) is a crucial enzyme responsible for maintaining the low intracellular Na+:K+ ratio essential for cell homeostasis and physiological function. This Mg2+-dependent P-type transport pump actively uptakes K+ and extrudes Na+ at the expense of hydrolyzing ATP, with a stoichiometry of 3Na+ for 2K+. The active form of Na, K-ATPase is an integral membrane protein complex composed of a catalytic α subunit and a glycosylated β subunit. In dogs, Na, K-ATPase plays a significant role in various cellular processes, including fluid secretion, nerve transmission, and muscle contraction. Notably, in canine prostate cancer, the expression of Na, K-ATPase is down-regulated, which is associated with metabolic transformation and malignancy progression. This down-regulation can influence citrate biosynthesis, zinc uptake, and energy metabolism, potentially promoting neoplastic development and metastasis.