Mouse Anti-Monkeypox and Vaccinia A13 Monoclonal Antibody

The A13 membrane protein is a conserved and essential component found in both the monkeypox virus and the vaccinia virus, which are members of the Orthopoxvirus genus. This protein is a virion-associated membrane protein that plays a significant role in the virus's life cycle, particularly in the assembly and egress of the virus from the host cell. A13 is implicated in the formation of the virus's envelope and may also contribute to immune evasion by interfering with host cell signaling pathways. As a target for antiviral development, the A13 Membrane Protein offers a unique opportunity due to its conserved nature across different poxviruses. Targeting A13 could potentially lead to the development of broad-spectrum antivirals effective against various members of the Orthopoxvirus genus. Understanding the molecular mechanisms by which A13 functions within the virus could reveal vulnerabilities that can be exploited therapeutically. The structural and functional characterization of A13 is therefore of great interest to researchers seeking to combat poxvirus infections and to enhance our preparedness against emerging or re-emerging viral threats.