Mouse Anti-Porcine Catechol-O-Methyltransferase (COMT) Monoclonal Antibody

Porcine catechol-O-methyltransferase (COMT) is an enzyme that plays a pivotal role in the metabolism of catecholamines, such as dopamine, adrenaline, and noradrenaline, by transferring a methyl group to their hydroxyl groups. This process is a critical step in the degradation and inactivation of these neurotransmitters, thereby regulating their levels in the synaptic cleft and influencing signal transduction in the central nervous system. As a molecular target, COMT is significant due to its involvement in various physiological and pathological processes. It has been implicated in the regulation of cognitive functions, mood, and pain perception, making it a potential therapeutic target for conditions such as schizophrenia, bipolar disorder, and Parkinson's disease, where catecholamine metabolism is disrupted.