Mouse Anti-Porcine Electron-Transfer-Flavoprotein Subunit Alpha (ETFA) Monoclonal Antibody

Porcine electron-transfer-flavoprotein subunit alpha (ETFA) is a vital component of the mitochondrial electron transport chain, playing a significant role in energy metabolism. ETFA, together with its beta subunit (ETFB), forms a heterodimeric enzyme that carries electrons from various flavoenzymes to the respiratory chain, facilitating the production of ATP. This enzyme is particularly important in fatty acid oxidation and amino acid catabolism, as it links these metabolic pathways to the electron transport chain. In pigs, ETFA is essential for maintaining metabolic homeostasis, and its dysfunction can lead to severe metabolic disorders. For instance, mutations in the ETFA gene can result in multiple acyl-CoA dehydrogenase deficiency (MADD), which is characterized by the accumulation of toxic metabolites and can lead to various health complications. The study of ETFA in pigs is crucial for understanding the molecular mechanisms underlying metabolic diseases and for developing therapeutic strategies.