Mouse Anti-Porcine Fk506 Binding Protein 2 (FKBP2) Monoclonal Antibody

Porcine Fk506 binding protein 2 (FKBP2) is an endoplasmic reticulum (ER)-resident protein with peptidyl-prolyl isomerase (PPIase) activity, which plays a crucial role in protein folding and processing within the cell. This protein is particularly important for the correct folding of proinsulin, a precursor to insulin, and its dysregulation has been implicated in the development of diabetes. FKBP2 interacts with proinsulin and the chaperone GRP94, and its inhibition can lead to increased proinsulin turnover, reduced intracellular levels, and the formation of high-molecular-weight complexes indicative of misfolding. The protein's function is not limited to proinsulin handling; it also participates in various cellular processes, including signaling, apoptosis, and transcription. FKBP2's role in these pathways is through direct binding and conformational changes of target proteins, acting as a molecular switch. Its interaction with the immunosuppressive drugs FK506 and rapamycin highlights its potential in therapeutic applications, particularly in regulating immune responses and cellular growth.