Mouse Anti-Porcine Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- and Steroid Delta-Isomerase 2 (HSD3B2) Monoclonal Antibody

Porcine hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2) is a crucial enzyme involved in the biosynthesis of all classes of hormonal steroids, playing a key role in the conversion of delta(5)-ene-3-beta-hydroxy steroid and the oxidative conversion of ketosteroids. Predominantly expressed in the adrenals and gonads, this enzyme is essential for steroidogenic tissues in pigs. Mutations in the HSD3B2 gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency, which can lead to severe health implications, including salt-wasting congenital adrenal hyperplasia. This gene and its encoded protein are not only vital for maintaining hormonal balance but also serve as a target for therapeutic interventions in conditions related to steroid hormone imbalances. The study of HSD3B2 in pigs can provide insights into the regulation of steroid metabolism and the development of strategies for the management of related diseases in both veterinary and human medicine.