Mouse Anti-Porcine Kv Channel Interacting Protein 4 (KCNIP4) Monoclonal Antibody

Porcine Kv channel interacting protein 4 (KChIP4) is a calcium-binding protein that plays a pivotal role in the modulation of voltage-gated potassium channels, particularly the Kv4 family. KChIP4, also known as CALP, is unique among the KChIP family as it contains a functional Kv4 channel inhibitory domain (KID) that can eliminate the fast inactivation of Kv4 currents. This protein is highly expressed in the brain and has been implicated in the regulation of neuronal excitability and cardiac electrophysiological function. KChIP4 interacts with Kv4 channels by binding to their N-terminus, which affects channel trafficking, surface expression, and gating properties. The interaction with Kv4 channels is crucial for the proper functioning of the nervous and cardiovascular systems, and alterations in KChIP4 expression have been linked to various neurological and cardiovascular diseases. Furthermore, KChIP4 has been shown to modulate other ion channels, such as KV1.5, contributing to the complex regulation of cellular excitability.