Mouse Anti-Porcine Membrane Metallo-Endopeptidase (MME) Monoclonal Antibody

Porcine membrane metallo-endopeptidase (PME) is an integral membrane protein with endopeptidase activity that is involved in the degradation of a variety of peptides, including insulin, IL6, and β-amyloids. This enzyme is particularly enriched in subcutaneous white adipose tissue (WAT) and has been implicated in the regulation of inflammatory response and insulin signaling in white preadipocytes. PME's role in adipose tissue is significant as it contributes to the metabolic properties that distinguish subcutaneous from visceral WAT. Higher expression levels of PME in subcutaneous WAT are associated with favorable insulin signaling and a reduced inflammatory response. Studies have shown that knockdown of PME in subcutaneous preadipocytes increases the inflammatory response to substance P and amyloid β aggregates, which is linked to increased basal insulin signaling and decreased insulin-stimulated signaling.