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Mouse Anti-Canine B-Raf Monoclonal Antibody

Cat. No.VD11N124

Product TypeAnimal-targeted Antibodies

Size 100 μL

Product Overview

BioVenic mouse monoclonal antibody is specific for canine B-Raf. It can be applied to WB, ICC/IF and IP assays of canine B-Raf.

Specifications

Application WB; ICC/IF; IP
Clonality Monoclonal
Classification Primary Antibody
Clone S13N76
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine B-Raf
Isotype IgG2
Immunogen Recombinant protein of B-Raf
Concentration 1.2 mg/mL
Conjugation Unconjugated
Preservative and Stabilizer 0.02% Sodium Azide
Buffer Phosphate Buffered Saline, 1% BSA, 50% Glycerol
Physical State Liquid

Target Information

Canine B-Raf, a serine/threonine-protein kinase, is a key component of the MAPK signaling pathway, which regulates cell growth, proliferation, and survival. Mutations in the B-Raf gene, particularly the BRAF V450E mutation, have been identified in various canine cancers, including urinary carcinomas, and are associated with the activation of this pathway, leading to uncontrolled cell division and tumor development. In dogs, the presence of BRAF mutations offers diagnostic and therapeutic opportunities, as targeting the BRAF/MAPK pathway may provide clinical benefits for dogs with these mutations, especially in cancers such as urothelial carcinoma.

Target Canine B-Raf
Target Synonym BRAF
Gene ID 475526
UniProt ID A0A8I3SCX1

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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