Mouse Anti-Porcine Rab Gtpase-Binding Effector Protein 2 (RABEP2) Monoclonal Antibody

Porcine Rab GTPase-binding effector protein 2 (RABEP2) is a critical regulatory molecule that orchestrates vesicle traffic within the cell. As a component of the Rab GTPase family, it plays a pivotal role in defining membrane identity and facilitating intracellular trafficking events. This protein functions by activating Rab GTPases through a nucleotide exchange factor (GEF), which is essential for the Rab proteins to transition from an inactive GDP-bound state to an active GTP-bound state. In pigs, RabGEFs are crucial for the spatiotemporal regulation of Rab localization and their functional diversity. They are involved in the recruitment of molecular motors for intracellular trafficking and the modulation of the actin cytoskeleton, which are vital for maintaining cellular compartment identity and regulating membrane trafficking. The interaction of RabGEFs with their specific Rab proteins is highly specific and is determined by the structural plasticity and sequence variability within the Rab proteins themselves.