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Recombinant Bovine Interleukin 1 Receptor Antagonist (IL1RN), N-His
Product Overview
BioVenic's Recombinant Bovine Interleukin 1 Receptor Antagonist (IL1RN), N-His is a recombinant protein expressed from E.coli expression system. Its predicted molecular weight is 20.9 kDa. The purity is greater than 95% (SDS-PAGE). The endotoxin level is <1 EU/μg (LAL). It can be used as a positive control or as an immunogen.
Specifications
Target Information
Interleukin 1 receptor antagonist is encoded by the IL1RN gene in cattle. It is an anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. It protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. Research showed that castration increased leukocyte mRNA levels of the IL1RN gene at 6 h after castration in cattle.
Shipping and Storage
This product is shipped with dry ice. Avoid repeated freezing and thawing. Store for 4 weeks at 2-8°C, for 12 months at -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH 7.4) to a concentration of 0.1-1.0 mg/mL. Aliquote the reconstituted solution to minimise freeze-thaw cycles.
References
- Yoo, S. et al. Effect of knife castration on leukocyte cytokine expression and indicators of stress, pain, and inflammation in Korean cattle bull calves. Animal bioscience. 2023, 36: 521-528.