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Recombinant Bovine Thrombopoietin (THPO), N-His
Product Overview
BioVenic's Recombinant Bovine Thrombopoietin (THPO), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is N/A. The purity is>97% (SDS-PAGE).
Specifications
Target Information
Bovine thrombopoietin (TPO) is a cytokine that plays a pivotal role in the development and differentiation of megakaryocytes and the production of platelets in cattle. As a key regulator in hematopoiesis, TPO is primarily produced in the liver and acts on the TPO receptor, activating JAK and STAT pathways, which stimulates megakaryocyte growth and platelet production. It is involved in the maintenance of hematopoietic stem cells and is essential for bone marrow function. TPO levels are inversely proportional to the rate of platelet production, and it is cleared by TPO receptors on platelets. In Bovine medicine, TPO is important for managing thrombocytopenic states and could potentially be used to improve yields from platelet apheresis. It represents a significant growth factor in veterinary applications for the treatment of various diseases affecting platelet counts.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquot as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimise freeze-thaw cycles.