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Recombinant Feline Beta-Galactosidase (GLB1)
Product Overview
BioVenic's Recombinant Feline Beta-Galactosidase (GLB1) is a recombinant protein expressed from E.coli. Its predicted molecular weight is 75.2 kDa. The purity is>85% (SDS-PAGE).
Specifications
Target Information
In felines, beta-galactosidase (GLB1) is a lysosomal enzyme that degrades glycosphingolipids like GM1 ganglioside and glycosaminoglycans such as keratan sulfate. It is crucial for maintaining neuronal function and connective tissue integrity. Mutations in the GLB1 gene cause GM1 gangliosidosis, a fatal neurodegenerative disease characterized by GM1 accumulation in neurons. GLB1 also contributes to elastic fiber formation by encoding elastin-binding protein. Studies in feline models have shown that delivering the GLB1 gene via AAV vectors can potentially treat GM1 gangliosidosis.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -20°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquot the reconstituted solution to minimize freeze-thaw cycles.