Recombinant Mouse H-2 Class II Histocompatibility Antigen Gamma Chain (CD74), C-mFc-His

Mouse H-2 Class II Histocompatibility Antigen Gamma Chain, or CD74, is part of the major histocompatibility complex class II molecule, involved in antigen presentation and immune response regulation. In mouse experiments, CD74 is used to study antigen presentation and immune response mechanisms. CD74 is a invariant chain that associates with MHC class II alpha and beta chains in the endoplasmic reticulum, facilitating their transport to the cell surface. During antigen presentation, CD74 is partially degraded to allow peptides to bind to MHC class II molecules. This process is essential for the presentation of exogenous antigens to CD4+ T cells, which is crucial for the initiation of adaptive immune responses. CD74 also functions as a receptor for macrophage migration inhibitory factor, linking it to the regulation of inflammation and immune cell trafficking. Research on CD74 has implications for understanding the molecular basis of antigen processing and presentation, as well as for developing therapeutic strategies to modulate immune responses in infectious diseases, autoimmune conditions, and cancer.