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Veterinary Therapeutic Protein and Peptide Phage Display Platform
Phage display technology is an advanced biotechnological method employed for in vitro screening of high-affinity ligands. This technique facilitates the identification of candidate molecules that demonstrate exceptional specificity and affinity from a diverse collection of protein or peptide sequences. BioVenic has established an innovative phage display platform tailored for veterinary therapeutic protein and peptide discovery, offering comprehensive services in phage library construction and phage display screening to advance the discovery phase of veterinary therapeutic proteins and peptides.
Phage Display Platform Overview
The phage selection method, referred to as biopanning, is an affinity selection technique utilized to isolate molecules that bind to specific targets. Biopanning based on phage display typically involves five screening steps to select veterinary therapeutic proteins and peptides. Typically, three to five rounds of biopanning are required to isolate proteins/peptides that bind specifically and with high affinity. To enhance the specificity and affinity of the proteins/peptides, each round of biopanning involves incrementally increasing the stringency. This is achieved by increasing the number of washing steps and reducing the concentration of the target molecule. After the biopanning process, phage ELISA and DNA sequencing are employed to identify specific phages that exhibit high affinity binding to the target.
Fig.1 The veterinary therapeutic protein and peptide phage display. (BioVenic Original)
Phage Display Services
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Phage Display Platform Technical Features
- Our phage libraries have large diversity sizes (approximately 1010 unique individual sequences).
- Our platform supports both in vitro (test tube-based) and in vivo (within living organisms) protein/peptide evolution processes, allowing for the optimization of protein/peptide functions under various conditions.
- The phage display platform can target and evolve multiple desired functions concurrently, enhancing the efficiency and breadth of therapeutic discovery and development.
Service Workflow
Phage display technology in BioVenic begins with a thorough consultation to understand client goals and tailor services. We then create diverse phage libraries, custom-built or from existing collections, to capture a wide array of potential binders. Our screening involves several rounds of panning to select phages with strong affinity and specificity for the target. Promising candidates undergo sequencing and detailed characterization to assess their binding properties. Finally, we deliver comprehensive reports and ongoing support, integrating the developed proteins into the client's research or product pipelines, ensuring advancements in both science and therapy. BioVenic also offers a one-stop solution for veterinary therapeutic protein and peptide development through its comprehensive phage display services, tailored to meet each client's specific needs.
Fig.2 The workflow for veterinary therapeutic protein and peptide phage display services. (BioVenic Original)
Why Choose Us?
Customized Service
Protein/peptide libraries and screening strategies are customized according to specific customer needs.
High-Throughput Screening
Phage display allows for the screening of vast libraries of veterinary peptides or proteins.
High Sensitivity
Capable of identifying peptides that interact with the target at very low concentrations.
Specificity and Affinity
Phage display facilitates the identification of ligands with high specificity and affinity towards their targets, which is crucial for developing therapeutic proteins or peptide.
Cost-Effective
Compared to other high-throughput screening methods, phage display is relatively cost-effective and does not require expensive equipment or reagents.
Professional Support
Provide professional technical support and follow-up services, including protein/peptide synthesis, purification and functional validation.
BioVenic leverages advanced phage display technology to expedite the discovery and development of veterinary therapeutic proteins and peptides. Our phage display platform is specifically designed for the discovery of veterinary therapeutic proteins and peptides. We offer comprehensive services, including phage library construction and phage display screening, to support your research and development efforts in animal health. Partner with us to leverage our expertise and elevate your veterinary therapeutic projects. For more information or to discuss your project needs, please contact us .