Mouse Anti-Canine Alpha Fetoprotein (AFP) Monoclonal Antibody

Canine alpha fetoprotein (AFP) is a glycoprotein that is primarily synthesized by liver cells and the yolk sac, with high concentrations present in fetal blood circulation that decrease after birth. It serves multiple functions including transport, bidirectional regulation of growth regulatory factors, immunosuppression, and T lymphocyte induction of apoptosis. AFP is closely associated with the occurrence and development of liver cancer and various tumors, showing high concentrations in these conditions and can be used as a positive detection indicator for various tumors. In dogs, AFP is mainly used clinically as a serum marker for the diagnosis and efficacy monitoring of primary liver cancer. Its role in immune regulation and promotion of immune escape in hepatocellular carcinoma makes it a significant target in canine oncology and potential immunotherapy approaches.