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Mouse Anti-Canine Matrix Metallopeptidase 2 (MMP2) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for canine matrix metallopeptidase 2. It can be applied to WB and IHC assays of canine matrix metallopeptidase 2.
Specifications
Target Information
Canine matrix metallopeptidase 2 (MMP-2), also known as gelatinase A or type-IV collagenase, is a zinc-dependent enzyme that plays a significant role in the proteolytic degradation of the extracellular matrix (ECM). It is particularly involved in tumor invasion and metastasis by degrading type IV collagen of the basement membrane. Additionally, MMP-2, along with its specific tissue inhibitor TIMP-2, may serve as a valuable prognostic indicator in canine oronasal cavity tumors. The enzyme's activity is further regulated by other MMPs and membrane-type MMPs (MT-MMPs), such as MT1-MMP, which is expressed on tumor cell surfaces and is crucial for the activation of proMMP-2.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Fukushima, Kazuhiro, et al. "Activation and localization of matrix metalloproteinase-2 and-9 in the skeletal muscle of the muscular dystrophy dog (CXMD J)." BMC musculoskeletal disorders 8 (2007): 1-11.