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Mouse Anti-Canine L1 Cell Adhesion Molecule (L1CAM) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for canine L1 cell adhesion molecule. It can be applied to WB, ICC/IF and FACS assays of canine L1 cell adhesion molecule.
Specifications
Target Information
Canine L1 cell adhesion molecule (L1CAM) is a transmembrane glycoprotein that plays a significant role in neural development and has been implicated in the progression of various types of cancer. It is involved in processes such as neurite outgrowth, fasciculation, cell adhesion, cell migration, myelination, and cell survival. L1CAM functions through homophilic interactions with other L1CAM molecules and heterophilic interactions with neural cell adhesion molecules like integrins or CD24, and other binding partners such as neurocan or neuropilin-1. The molecule can also be cleaved by metalloproteases, resulting in a soluble ectodomain and a membrane-bound cytosolic domain, which can further influence cell signaling and migration.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Kukielka, Gilbert L., et al. "Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium." The Journal of clinical investigation 92.3 (1993): 1504-1516.