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Mouse Anti-Canine L1 Cell Adhesion Molecule (L1CAM) Monoclonal Antibody

Cat. No.VD11N139

Product TypeAnimal-targeted Antibodies

Size 100 μL

Product Overview

BioVenic mouse monoclonal antibody is specific for canine L1 cell adhesion molecule. It can be applied to WB, ICC/IF and FACS assays of canine L1 cell adhesion molecule.

Specifications

Application WB; ICC/IF; FACS
Clonality Monoclonal
Classification Primary Antibody
Clone S14N2
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine L1 Cell Adhesion Molecule
Isotype IgG1
Immunogen Recombinant protein of L1 cell adhesion molecule
Concentration 1 mg/mL
Conjugation Unconjugated
Preservative and Stabilizer 0.02% Sodium Azide
Buffer Phosphate Buffered Saline, 1% BSA, 50% Glycerol
Physical State Liquid

Target Information

Canine L1 cell adhesion molecule (L1CAM) is a transmembrane glycoprotein that plays a significant role in neural development and has been implicated in the progression of various types of cancer. It is involved in processes such as neurite outgrowth, fasciculation, cell adhesion, cell migration, myelination, and cell survival. L1CAM functions through homophilic interactions with other L1CAM molecules and heterophilic interactions with neural cell adhesion molecules like integrins or CD24, and other binding partners such as neurocan or neuropilin-1. The molecule can also be cleaved by metalloproteases, resulting in a soluble ectodomain and a membrane-bound cytosolic domain, which can further influence cell signaling and migration.

Target Canine L1 Cell Adhesion Molecule
Target Synonym L1CAM
Gene ID 492244
UniProt ID A0A8C0T3U3

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Kukielka, Gilbert L., et al. "Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium." The Journal of clinical investigation 92.3 (1993): 1504-1516.
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