Mouse Anti-Canine Thiopurine S-Methyltransferase (TPMT) Monoclonal Antibody

Canine thiopurine S-methyltransferase (TPMT) is a key enzyme involved in the metabolism of thiopurine drugs, such as azathioprine, which are used in the treatment of various immune-mediated diseases and cancers in dogs. Genetic polymorphisms in the TPMT gene lead to significant inter-individual variation in enzyme activity, affecting the toxicity and therapeutic efficacy of these drugs. Low TPMT activity increases the risk of myelosuppression from azathioprine and 6-mercaptopurine, while high TPMT activity can result in poor drug efficacy. This enzyme is crucial for personalized medicine in dogs, as it helps determine the appropriate dosing of thiopurine drugs to balance therapeutic benefits and adverse effects. Understanding canine TPMT activity is essential for optimizing treatment outcomes and minimizing drug-related toxicities in veterinary medicine.