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Mouse Anti-Herpes Simplex Virus (HSV) Type 1&2 Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for herpes simplex virus type 1 and 2. It can be applied to ELISA and IF of herpes simplex virus type 1 and 2.
Specifications
Target Information
Herpes simplex virus (HSV), both types 1 and 2, are enveloped viruses that contain a variety of glycoproteins on their surface, with Glycoprotein D (gD) being one of the most critical for viral infection. gD is a major antigenic determinant and is essential for the initial stages of the virus's interaction with host cells. This glycoprotein plays a multifaceted role in the HSV life cycle. It is involved in the attachment of the virus to the host cell by binding to specific receptors, such as HVEM (Herpesvirus Entry Mediator) and nectin-1. This binding facilitates the fusion of the viral envelope with the host cell membrane, allowing the virus to enter and initiate infection.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C - -70°C(up to 12 months) on receipt. Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Hook, Lauren M., et al. "Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs." PLoS Pathogens 14.5 (2018): e1007095.