Mouse Anti-Nipah Virus Fusion Protein Site IV Monoclonal Antibody

The nipah virus fusion protein F2, part of the paramyxovirus family, contains a series of cleavage sites that are crucial for its activation. Among these, site IV is a critical juncture for the F2 protein's maturation, although the exact role and mechanism of site IV in the Nipah virus are not extensively detailed in the literature. Generally, for paramyxoviruses, cleavage at specific sites within the F2 protein is essential for its transition from a pre-fusion to a post-fusion state, which is necessary for the fusion of the viral envelope with the host cell membrane. Site IV, if present and functionally analogous to other paramyxoviruses, could be a point of regulation or a checkpoint in the F2 protein's lifecycle. Targeting this site could potentially interfere with the protein's ability to undergo the necessary conformational changes for fusion, thereby inhibiting the virus's entry into host cells.