Mouse Anti-Porcine Homer Scaffold Protein 1 (HOMER1) Monoclonal Antibody

Porcine homer scaffold protein 1 (HSPC020), also known as HOMER1, is an important postsynaptic density protein that plays a crucial role in organizing signaling complexes at the synapse. It is involved in the regulation of intracellular calcium levels, which are essential for muscle contraction and synaptic plasticity. HOMER1 is highly expressed in the central nervous system and has been implicated in the development and function of neuromuscular junctions. In pigs, HOMER1 has been identified as a candidate gene for piglet splay leg syndrome, a complex genetic disorder that affects newborn piglets. Studies have found significant associations between polymorphisms in the HOMER1 gene and the occurrence of this syndrome. Notably, certain SNPs within the intronic regions of HOMER1 have been shown to affect the promoter activity of the gene, potentially influencing its transcription and, consequently, the development and function of skeletal muscles.