Mouse Anti-Porcine Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody

Porcine proliferating cell nuclear antigen (PCNA), a homologue of the human PCNA, is a key protein in the cell cycle of pigs, playing a central role in DNA replication and repair. As a cofactor for DNA polymerase delta, PCNA is essential for the processivity of DNA synthesis, ensuring the accurate and efficient replication of genetic material. It is also implicated in other DNA transactions, including base excision repair, nucleotide excision repair, and mismatch repair. The expression of PCNA is tightly regulated and is typically elevated during the S phase of the cell cycle, reflecting the increased demand for DNA synthesis. Its presence in the cell nucleus serves as a reliable marker for cells that are actively proliferating. Given its role in DNA replication, PCNA is a critical target for research in cell biology, particularly in the context of cancer, where uncontrolled cell proliferation is a hallmark.