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Mouse Anti-Sheep Prion Protein (PRNP) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for sheep prion protein. It can be applied to ELISA and IHC assays of sheep prion protein.
Specifications
Target Information
Sheep prion protein (PrP) is a central component in the study of prion diseases, particularly scrapie, which is a fatal neurodegenerative disease in sheep. PrP exists in two forms: the normal cellular form (PrPC) and the disease-associated form (PrPSc). The conversion of PrPC to PrPSc is the key event in the pathogenesis of prion diseases. Genetic variations in the prion protein gene (PRNP), especially at codons 136, 154, and 171, are associated with differences in scrapie susceptibility.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Bannach, Oliver, et al. "Detection of prion protein particles in blood plasma of scrapie infected sheep." PloS one 7.5 (2012): e36620.